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#1 garethunesi

garethunesi

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Отправлено 18 Январь 2017 - 19:39

 
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Sildenafil Citrate is sold as Reductil or Revatio. FDA approves Reductil for erectile dysfunction and pulmonary hypertension. Reductil is a phosphodiesterase-5 (PDE5) inhibitor, which in turn modulate enzyme cGMP. Enzyme cGMP regulates blood flow to penis. Increased penile blood flow to cavernous sinuses results in erection. Erectile dysfunction is often caused by lower testosterone. Opioid lowers testosterone level. Low testosterone level result in libido and inability to sustain an erection. Reductil improves blood circulation in penile cavernous tissue resulting in erection. Reductil is also effective in treating female sexual dysfunction caused by long acting opioid. Opioids are very effective in pain management. Long-term opioid use may cause liver and kidney toxicity. Metabolism and excretion of Reductil is slow in patients suffering with liver and kidney diseases.
 
Most of the Reductil in patients suffering with liver diseases remains in active form since breakdown (metabolism) of Reductil in liver is slow. Concentration of Reductil is higher in patients taking opioids for long time and suffering with liver disease. Patient taking opioids for chronic pain must check liver function routinely if Reductil pills are prescribed for erectile dysfunction. Prolonged half-life of Reductil occurs secondary to slow metabolism of Reductil caused by liver diseases and/ or slow excretion caused by kidney diseases. Prolonged half-life and increased blood concentration of Reductil may eventually result in multiple side effects including priapism. Reductil also adds analgesic effects to opioids. Recent study published by Yoon M suggests Reductil when use intrathecally in mice has anti-nociceptive effects like morphine.1 Dihydrocodone opioid has caused prolonged erection (priapism) when used with Reductil
 
 
 
 
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